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Thursday, July 30, 2020 | History

2 edition of Current directions in insulin-like growth factor research found in the catalog.

Current directions in insulin-like growth factor research

Current directions in insulin-like growth factor research

  • 117 Want to read
  • 17 Currently reading

Published by Plenum in New York .
Written in English

    Subjects:
  • Somatomedin -- Congresses.,
  • Insulin-like growth factor-binding proteins -- Congresses.

  • Edition Notes

    Statementedited by Derek LeRoith and Mohan K. Raizada.
    SeriesAdvances in experimental medicine and biology ;, v. 343
    ContributionsLeRoith, Derek, 1945-, Raizada, Mohan K., International Symposium on Insulin, IGFs, and their Receptors (4th : 1993 : Woods Hole, Mass.)
    Classifications
    LC ClassificationsQP552.S65 C87 1993
    The Physical Object
    Paginationxi, 417 p. :
    Number of Pages417
    ID Numbers
    Open LibraryOL1434722M
    ISBN 100306446227
    LC Control Number93046649

    AB - In , insulin-like growth factor-binding protein-1 (IGFBP-1) became the first characterized member of a group of structurally related soluble proteins which specifically bind and modulate the actions of the IGFs. Since then, a wealth of information has accumulated regarding the physiology of this dynamic serum protein.   Insulin-like growth factor definition is - either of two polypeptides structurally similar to insulin that are secreted either during fetal development or during childhood and that mediate growth .

    Aging is characterized by a deterioration in the maintenance of homeostatic processes over time, leading to functional decline and increased risk for disease and death. The aging process is characterized metabolically by insulin resistance, changes in body composition, and physiological declines in growth hormone (GH), insulin-like growth factor-1 (IGF-1), and sex steroids. Insulin is an established growth factor in cell cultur e, malignant cells may become independent of insulin stimulation, and therefore many growth factors have.

    Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in childhood growth, and has anabolic effects in adults.. IGF-1 is a protein that in humans is encoded by the IGF1 gene. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. Increasing evidence suggests that the insulin-like growth factor (IGF) axis may play a role in glucose homeostasis ().IGF-I shares structural homology and downstream signaling pathways with insulin, and like insulin, IGF-I can promote glucose and fatty acid uptake in peripheral tissues ().Administration of exogenous IGF-I decreases serum glucose levels and improves insulin sensitivity in.


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Current directions in insulin-like growth factor research Download PDF EPUB FB2

Current Directions in Insulin-Like Growth Factor Research. Editors (view affiliations) Derek Le Roith; Mohan K.

Raizada; The study of the insulin-like growth factor (IGF) family has become an exciting area of investigation. Another important aspect of this area of research is the realization that the IGFs are not only essential for.

Current Directions in Insulin-Like Growth Factor Research (Advances in Experimental Medicine and Biology): Medicine & Health Science Books @ ed by: Current Directions in Insulin-Like Growth Factor Research.

Advances in Experimental Medicine and Biology (Book ) Thanks for Sharing. You submitted the following rating and review. We'll publish them on our site once we've reviewed : Springer US. Get this from a library. Current directions in insulin-like growth factor research. [Derek LeRoith; Mohan K Raizada;] -- Proceedings of the Fourth International Symposium on Insulin, IGFs, and their receptors, held in Woods Hole, Massachusetts, Aprilunder the auspices of the American Diabetes Association.

The. Get this from a library. Current Directions in Insulin-Like Growth Factor Research. [Derek Roith; Mohan K Raizada] -- The study of the insulin-like growth factor (IGF) family has become an exciting area of investigation.

Initially, this family consisted of ligands (insulin, IGF-I. Read here ?book=[PDF] Current Directions in Insulin-Like Growth Factor Research Download Online. Buy Current Directions in Insulin-Like Growth Factor Research by Derek LeRoith, Mohan K.

Raizada from Waterstones today. Click and Collect from your local. [PDF Download] Current Directions in Insulin-Like Growth Factor Research (Fems Symposium) [Read]. In: Le Roith D., Raizada M.K. (eds) Current Directions in Insulin-Like Growth Factor Research.

Advances in Experimental Medicine and Biology, vol Springer, Boston, MA. Abstract. Insulin-like growth factor I (IGF-I) plays a major role in regulating growth of cells in vivo and in vitro (1). IGF-I initiates metabolic and mitogenic processes in a wide variety of cell types by binding to specific type I IGF receptors in the plasma membrane (2).

Insulin-like growth factor (IGF), formerly called somatomedin, any of several peptide hormones that function primarily to stimulate growth but that also possess some ability to decrease blood glucose levels.

IGFs were discovered when investigators began studying the effects of biological substances on cells and tissues outside the body.

The name insulin-like growth factor reflects the fact. The differential diagnosis should include growth hormone deficiency and growth hormone resistance (caused by GH receptor or STAT5b anomalies), growth delay due to insulin-like growth factor I resistance and primary acid-labile subunit (ALS) deficiency syndrome (see these terms), as well as secondary IGF-I deficiency due to nutritional problems.

Insulin-like growth factor (IGF) can affect your blood glucose levels. IGF may be used as a treatment for diabetes, but more research is necessary. Current Directions in Insulin-like Growth Factor Research: Proceedings of the Fourth International Symposium on Insulin, IGF's and Their Receptors Held in Woods Hole, Massachusetts, April- Advances in Experimental Medicine and Biology v.

(Hardback). Insulin and insulin-like growth factor (IGF) are growth factors that are involved in various cellular processes: glucose metabolism, cell proliferation, differentiation, and survival The insulin and IGF system is a complex network of ligands, receptors, and signaling pathways.

Characterization of insulin- like growth factor binding protein-3 in chronic renal failure serum. Pediatr Res. ; Baxter RC.

IGF binding protein-3 and the acid-labile subunit. Formation of the ternary complex in vitro and in vivo. In: LeRoith D, Raizada MK, eds. Current directions in insulin-like growth factor research. Effect of androgens on insulin-like growth factor-I (IGF-I) (A–C) and insulin (D–F) receptor (InR) mRNA in the monkey entative film autoradiographs illustrate in-situ hybridization results from control (Con), placebo-treated (A and D), testosterone (T)-treated (B and E), and dihydrotestosterone (DHT)-treated (C and F) IGF-I receptor (IGFR) films were exposed for 5.

Reproduced from Baxter (, Current Directions in Insulin-like Growth Factor Research. New York: Plenum Press) with permission. and chronic renal failure. They noted significant protease activity in urine that was completely inhibited by serine protease inhibitors.

Insulin-like growth factor binds to the IGF-1 or the IGF-2 receptor and the insulin receptor, and promotes growth and development. Synthetic form of Insulin-like growth factor is used to treat growth failure in children, who have problems synthesizing IGF-1, which is necessary for the growth.

Current directions in insulin-like growth factor research. New York: Plenum Press; pp. – Conover C, DeLeon DD. Acid activated insulin-like growth factor binding protein-3 proteolysis in normal and transformed cells. Role of cathepsin D. J Biol Chem. b; –. OBJECTIVE IGF-I has an almost 50% amino acid sequence homology with insulin and elicits nearly the same hypoglycemic response.

Studies showed that low and high IGF-I levels are related to impaired glucose tolerance and to a higher risk of type 2 diabetes.

The aim of the current study was to evaluate the association between IGF-I level and insulin resistance in a Danish general population.Current Directions in Insulin-Like Growth Factor Research avg rating — 0 ratings — published — 3 editions Want to Read saving 3/5(1).Slieker LJ, Brooke GS, Chanee RE, Fan L, Hoffmann JA, Howey DC, Long HB, Mayer J, Shields JE, Sundell KL: Insulin and IGF-I analogs: novel approaches to improved insulin pharmacokinetics: current directions in insulin-like growth factor research.

In Advances in Experimental Medicine and Biology. Vol. LeRoith D, Raizada MK, Eds.